• Conference program

    Wednesday 20th October 2010

    17:00 Registration
    18:00 Opening Address
    Professor Richard Carter, The University of Edinburgh, UK
    18:45 Poster viewing
    20:00 End of Day 1

    Thursday 21st October 2010

    08:00 Registration & Coffee
    08:30 Keynote Address
    Epidemiology of malaria resistance or Artemisinin: resistance or temporary tolerance
    Carol Sibley, University of Washington, USA

    Session 1: Advances in understanding parasite biology and host-parasite interactions that are relevant to disease and treatment
    Chair: Kiaran Kirk, The Australian National University, Australia


    09:00 Invasion and modification of the host erythrocyte
    Brendan Crabb, Burnet Institute, Australia
    09:20 Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte
    Jake Baum, Walter and Eliza Hall Institute, Australia
    09:35 Liver stage malaria
    Maria M. Mota, Institute of Molecular Medicine, Portugal
    09:55 Transporters of parasites as drug targets: tempting but underexploited
    Henry Staines, St George's University of London, UK
    10:15 Polyamine uptake in the malaria parasite, Plasmodium falciparum, is dependent on the parasite’s membrane potential
    Braam Louw, University of Pretoria, South Africa
    10:30 A comprehensive survey of protein palmitoylation in late blood-stage Plasmodium falciparum
    Matthew L.Jones, Wellcome Trust Sanger Institute, UK
    10:45 Coffee Break

    Session 2: Assimilating genome-wide analyses of parasites to provide new tools for vaccines and drug discovery projects, as well as understanding the mechanisms of resistance
    Chair: Stephen Ward, Liverpool School of Tropical Medicine, UK


    11:15 Metabolomics approaches to understanding host parasite interaction
    Kellen Olszewski, Princeton University, USA
    11:35 Systematic gene knockout in P. berghei for analysis gene functions. Current status, how to extrapolate to human parasites.
    Olliver Billker, The Wellcome Trust Sanger Institute, UK
    11:55 Understanding Plasmodium sexual stage and zygote development and their translation
    Andy Waters, University of Glasgow UK
    12:15 Investigating transcriptional regulation of Plasmodium falciparum upon drug perturbation
    Tharina van Brummelenssion, CSIR, South Africa
    12:30 Ancient out-of-Africa migration of Plasmodium falciparum along with modern humans
    Kazuyuki Tanabe, Osaka University, Japan
    12:45 A library of functional recombinant Plasmodium falciparum merozoite surface proteins
    Cecile Wright-Crosnier, Wellcome Trust Sanger Institute
    13:00 Lunch

    Session 3: Vector biology: New approaches to vector control of plasmodium parasites
    Chair: Hilary Hurd, Keele University, School of Life Sciences


    14:00 Push-pull strategies for vector control
    Willem Takken, Wageningen University, Netherlands
    14:20 Studies on the breeding swarms of Anopheles gambiae complex in malaria control perspective
    Benoît S. Assogba, Benin
    14:35 Larval time-to-hatch and insecticide resistance in the major malaria vector Anopheles gambiae from Ghana
    Basil Brooke, National Institute for Communicable Diseases, Johannesburg
    14:50 Characterization and comparative sequence analyzes of GABA receptor gene in Asian main malaria mosquito, Anopheles stephensi
    Navid Dinparast Djadid, Pasteur Institute of Iran, Iran
    15:05 Sugar-fermenting yeast as an organic source of carbon dioxide to attract the malaria mosquito Anopheles gambiae s.s.
    Renate Smallegange, Wageningen University, The Netherlands
    15:20 Intra-host dynamics of mixed species malaria parasite infections in mice and mosquitoes
    Richard Culleton, Nagasaki University, Japan
    15:35 The role of LCCL proteins in malaria transmission
    Sadia Saeed, London School of Hygiene & Tropical Medicine, UK
    15:50 Coffee Break

    Session 4: Emerging parasites: Recently discovered knowlesi in humans that is providing new insights into pathophysiology of malarial infections
    Chair: David Sullivan, Johns Hopkins University, USA


    16:05 Insights from monkey malaria that can change thinking about human infections
    Janet Cox-Singh, St George's University of London, UK
    16:25 P. ovale
    Colin Sutherland, London School of Hygiene & Tropical Medicine, UK
    16:55 P vivax: The Duffy dogma revisited
    Peter Zimmerman, Case Western Reserve University, USA
    17:15 Adaptation of in vitro cytoadherence assay to Plasmodium knowlesi field isolates
    Farrah A Fatih, St George’s University of London, UK
    17:30 Origin of the human malaria parasite Plasmodium falciparum in gorillas
    Julian C Rayner, Wellcome Trust Sanger Institute, UK
    17:45 Wild chimpanzees are infected with homologous types of human malaria
    Marco Kaiser, Robert Koch-Institute, Germany
    18:00 Poster Viewing
    19:00 End of Day 2
    19:30 Coaches depart for dinner
    20:00 Conference Dinner at Dynamic Earth

    Friday 22nd October 2010

    Session 5: Revisiting the sequestration and cytokine/mediator models for pathogenesis
    Chair: Sanjeev Krishna, St George’s University of London, UK


    08:30 Coffee
    09:00 Var2CSA binding
    Ali Salanti, University of Copenhagen, Denmark
    09:20 Retinopathy and microcirculation in adult severe malaria
    Richard J Maude, Mahidol -Oxford Tropical Medicine Research Unit, Thailand
    09:40 Variant surface antigens in cerebral malaria: distinct from others and similar to each other?
    Agnès Aubouy, Institut de Recherche pour le Développement (IRD), France
    09:55 Transfer of 4-hydroxynonenal, a inhibitory hemozoin (HZ) product, from HZ or HZ-laden phagocytes to developing human erythroid cells. A model for erythropoiesis inhibition in malaria anemia
    Paolo Arese, University of Torino Medical School, Italy
    10:10 Molecular Epidemiology of Force of Infection in malaria
    Ingrid Felger, Swiss Tropical and Public Health Institute, Switzerland
    10:25 Immunopathology and Dexamethasone Therapy in a new Model for Malaria-Associated Acute Respiratory Distress Syndrome
    Philippe E. Van den Steen, University of Leuven, Belgium
    10:40 Coffee

    Session 6: Drug discovery - renewed vision and role in malaria control and elimination
    Chair: Henri Vial, CNRS University of Montpellier


    11:10 Keynote Address
    New drug treatments in the portfolio
    Tim Wells, Medicines for Malaria Venture (MMV), Switzerland
    11:40 Basic biology
    Stephen Ward, Liverpool School of Tropical Medicine, UK
    12:00 Refreshed approaches to the therapy of malaria – the case of natural medicine
    Hagai Ginsburg, The Hebrew University of Jerusalem, Israel
    12:20 Progress in the development of Reversed Chloroquine molecules as antimalarial therapy
    David H. Peyton, Portland State University, USA
    12:35 Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A and derivatives
    Angus Bell, Trinity College Dublin, Ireland
    12:50 Development of a Novel Drug for Uncomplicated Malaria Targeting the Mitochondrial NADH: Quinone Oxidoreductase
    Giancarlo Biagini, Liverpool School of Tropical Medicine, UK
    13:05 Antimalarial activity of ulein and a proof of its action on the Plasmodium falciparum digestive vacuole
    Alaíde Braga, Universidade Federal de Minas Gerais, Brazil
    13:25 Identification of genetic markers of resistance to Artemisinin Combination Therapy in the rodent model Plasmodium chabaudi
    Louise Rodrigues, Instituto Instituto de Higiene e Medicina Tropical Universidade Nova de Lisboa, Portugal
    13:40 Lunch

    Session 7: Immunology and vaccine development
    Chair: Alister Craig, Liverpool School of Tropical Medicine UK


    14:25 Sanaria malaria extraction through vaccination
    Dr. Peter Billingsley, Sanaria, USA
    14:45 Viral vectored transmission blocking vaccines against Plasmodium falciparum
    Melissa Kapulu, University of Oxford, UK
    15:00 Impact of protective haemoglobins C and S on P. falciparum malaria transmission in endemic area
    Louis-Clément Gouagna, Institut de Recherche pour le Développement, France
    15:15 Complete abrogation of sporozoite-induced sterile immunity by blood stage parasites of homologous and heterologous malaria species
    Megumi Inoue, Nagasaki University, Japan
    15:30 Predicted impact of mosquito-stage transmission-blocking vaccines using an ensemble of microsimulations
    Aurelio Di Pasquale, Swiss Tropical and Public Health Institute, Switzerland
    15:45 A micro-bead device to explore Plasmodium falciparum-infected, spherocytic or aged red blood cells prone to mechanical retention by spleen endothelial slits
    Innocent Safeukui, Institut Pasteur, France
    16:00 Coffee

    Session 8: Disease Control: Vector control options are constantly evolving, whether by pesticide, sterile insect technique or biological control. What else is on the horizon?
    Chair: Marcel Hommel, University of Liverpool, Editor-in-Chief, Malaria Journal, UK


    16:25 The elimination roadmap
    Marcel Tanner, Swiss Tropical and Public Health Institute, Switzerland
    16:45 Integrated vector management (IVM): from concept to practice
    Henk van den Berg, Laboratory of Entomology, Wageningen University, The Netherlands
    17:05 Modeling the effects of vector control interventions in reducing malaria transmission, morbidity and mortality
    Konstantina Boutsika, Swiss Tropical & Public Health Institute, Switzerland
    17:20 Controlling malaria in Niger with bednets: how to take the Big Picture?
    Jean-Bernard Duchemin, Institut Pasteur, France
    17:35 Household size explains successful malaria eradication
    Lena Hulden, University of Helsinki, Finland
    17:40 What has been the contribution of the first Global Fund grant (2003-2006) to malaria control and health system strengthening in Timor-Leste?
    Joao S Martins, University of New South Wales, Australia
    17:55 Closing remarks
    18:05 Close of Day 3
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    Malaria Journal is a peer-reviewed, open access journal publishing exclusively articles on malaria. It aims to bring together knowledge from the different specialties involved in this very broad discipline, from the bench to the bedside.

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